Examining the impact of the organizational immune system on strategic entrepreneurship in pharmaceutical companies: The mediating role of organizational innovation

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Abstract

This investigation fills a significant knowledge gap by examining the impact of internal organizational procedures on strategic outcomes in ever-moving markets. In particular, the influence of the organizational immune system (OIS) on the accomplishment of organizational innovation (OI) and strategic entrepreneurship (SE). The study also focused on pharmaceutical businesses listed on the Amman Stock Exchange in Jordan to survey how OI intermediated the link between OIS and strategic business. A total of 181 individuals at the managerial level (including managers, representatives and subordinates) contributed to the survey. Partial least squares structural equation modeling (PLS-SEM) was used to analyze the data. It has been shown that both OI and SE are significantly influenced by the organization’s immune system. The results also showed that the link between OIS and SE was mediated by OI. This research is useful for organizations looking to be more entrepreneurial in their strategic approach, as it shows how an organization’s immune system can be used to drive innovation within the company, which in turn leads to long-term success.

Keywords: Organizational Innovation, Strategic Entrepreneurship, Organizational Immune System, Jordanian Pharmaceutical Companies

Authors’ individual contribution: Conceptualization — A.A.T. and M.A.I.A.K.; Methodology — A.A.T. and M.A.I.A.K.; Formal Analysis — M.A.I.A.K.; Writing — Original Draft — M.A.I.A.K.; Writing — Review & Editing — A.A.T. and M.A.I.A.K.

Declaration of conflicting interests: The Authors declare that there is no conflict of interest.

JEL Classification: M1, M10, M19

Received: 12.07.2025
Revised: 24.09.2025; 23.10.2025; 26.01.2026
Accepted: 25.02.2026
Published online: 02.03.2026

How to cite this paper: Al Tweijer, A., & Al Khasabah, M. A. I. (2026). Examining the impact of the organizational immune system on strategic entrepreneurship in pharmaceutical companies: The mediating role of organizational innovation. Corporate and Business Strategy Review, 7(2), 49–60. https://doi.org/10.22495/cbsrv7i2art5